Esme Handley, 3, of West Norwood, south London

A 3-yr-aged woman who won housands of on-line followers as she battled leukaemia died on New Year’s Working day, her moms and dads have announced.

Esme Handley was diagnosed when she was just 22 months aged after establishing a substantial bruise on a household holiday getaway to Greece.  

Her mother and father Rebecca and Will broke the heart-breaking information on Facebook website page Esme Lionheart – so named mainly because of her enjoy of lions.

They reported: ‘If you glance to the sky tonight you will see a star shining brighter than any other.

‘Our darling lady went onwards with her journey at midday now. She was tranquil and in our arms and realized how ridiculously adored she was.

‘Esme Grace Angela Handley 13.08.2016 – 01.01.2020.’

Rebecca, 38, and Will, 43, faced a struggle to attempt and save their only daughter following her prognosis.

They learned she experienced the substantial threat acute myeloid leukaemia during a family members journey to Greece. After Esme fell above a bruise did not go absent, and after Googling her signs or symptoms, both of those mothers and fathers grew to become anxious.

Her parents Rebecca (pictured) and Will broke the heart-breaking news on Facebook page Esme Lionheart - so named because of her love of lions

Her mom and dad Rebecca (pictured) and Will broke the heart-breaking information on Fb page Esme Lionheart – so named mainly because of her like of lions

In November, her parents admitted that Esme could no longer expect to be cured and said their child had simply had enough

In November, her mothers and fathers admitted that Esme could no for a longer time be expecting to be fixed and mentioned their youngster experienced simply just had ample

Rebecca, 38, and Will, 43, faced a battle to try and save their only daughter following her diagnosis

Rebecca, 38, and Will, 43, faced a battle to try and conserve their only daughter subsequent her diagnosis 

She was taken to clinic in Greece in which the diagnosis was verified.

Esme was presented a stem cell transplant in September 2018 together with three rounds of chemotherapy but immediately after 6 months the leukaemia returned in the kid’s bone marrow.

The family members were not eligible for a 2nd transplant on the NHS and were being faced with boosting £500,000 privately for the urgent therapy.

In November, her mother and father admitted that Esme could no more time assume to be cured and stated their boy or girl had simply had plenty of.

They explained: ‘Since prognosis we have usually spoken about a metaphorical ”sealed envelope” that includes Esme’s destiny. Yesterday we received to open that envelope and it was not what we experienced hoped.

Esme was given a stem cell transplant in September 2018 alongside three rounds of chemotherapy

Esme was presented a stem cell transplant in September 2018 alongside a few rounds of chemotherapy 

The parents said: 'If you look to the sky tonight you will see a star shining brighter than any other'

The parents stated: ‘If you look to the sky tonight you will see a star shining brighter than any other’

One parent said she was devastated for the couple and sent them 'so so so much love and strength'. Another Facebook user said 'we are all with you and she will be forever in our hearts'

One particular dad or mum stated she was devastated for the couple and sent them ‘so so so a lot really like and strength’. An additional Facebook user explained ‘we are all with you and she will be for good in our hearts’

‘The leukaemia is out of manage and there is very little far more which can be done.

‘We have spoken with every single solitary main paediatric expert globally, attempted all readily available medications (some of which usually are not even accredited in young ones), explored a preposterous quantity of health supplements and complementary medications, had therapeutic circles significantly and extensive sending prayers…

‘But it truly is not been adequate. We really don’t get to preserve our little one.

Girl who won backing of thousands as she battled blood cancer died on New Year's Day

‘Throughout her procedure Esme has been the epitome of resilience, positivity and cheekiness, and justifies a shot at a everlasting overcome for life’

‘And to be correctly sincere, even if there was anything else they could arrive up with, proper now, I’m not sure we would be able to pursue it. It is really quite obvious to see that Esme has just experienced more than enough… and who could blame her?

‘Esme thrives when she’s outdoor but all she has regarded for 18 months is hospitals. The remedy she has had would not be tolerated by most older people.

‘She has been continually pumped total of prescription drugs had hundreds of blood transfusions effectively come as a result of just one stem mobile transplant experienced operation for a few Hickman strains into her coronary heart experienced various tubes shoved up her nose and drops in her eyes, endured numerous horrendous infections which includes a variety of pneumonia a few times lost her hair misplaced her fingernails vomited day by day, had her skin crack down, crack, be burnt from chemo almost died from sepsis nearly died from anaphylaxis been blue-lighted to PICU just after having a seizure which quickly left her in a vegetative point out thanks to a fungal mind an infection… and it goes on.

‘Whilst we would do completely anything for her, Just about anything, I’m also not certain how substantially much more we can tolerate possibly.’

A thirty day period afterwards, they explained the heartbreaking cocktail of soreness management Esme experienced to bear to soften her ‘ever-escalating suffering.’

At the time, her dad and mom posted: ‘It’s now 3 weeks to the working day that we learnt that Esme’s story will not have the happy ending we’ve all prayed for, 3 lengthy weeks in which we’ve experienced to ponder the unthinkable and bear witness to Esme’s ever-escalating struggling.

Her parents said: 'It's very clear to see that Esme has simply had enough... and who could blame her?'

Her dad and mom reported: ‘It’s incredibly crystal clear to see that Esme has simply just had plenty of… and who could blame her?’ 

Now Will and Rebecca, of West Norwood, south London, hope to donate money in Esme's name

Now Will and Rebecca, of West Norwood, south London, hope to donate dollars in Esme’s name 

‘In the initial pair of months 1 of the major difficulties was accepting that the team’s objective was no extended to treatment but just to deal with discomfort.

WHAT IS ACUTE MYELOID LEUKAEMIA?

Acute myeloid leukaemia (AML) is a sort of blood most cancers that starts in young white blood cells in the bone marrow.

AML has an effect on all over a person in 200 gentlemen and a person in 255 women of all ages in the Uk at some point in their lives.

Somewhere around 19,500 new cases arise each and every 12 months in the US. 

It is most normally diagnosed in older men and women.

Signs or symptoms can include things like:

  • Tiredness
  • Fever
  • Regular bacterial infections
  • Bruising or bleeding easily, together with nosebleeds or major periods
  • Body weight loss
  • Bone and joint suffering
  • Breathlessness
  • Swollen abdomen
  • Pale pores and skin

AML’s exact trigger is unclear, having said that, hazards incorporate: 

  • Cigarette smoking
  • Currently being chubby
  • Radiation publicity
  • Past chemotherapy
  • Particular blood issues, such as myelodysplastic syndrome
  • Some immune problems, like rheumatoid arthritis

AML is normally taken care of via chemotherapy. A bone marrow or stem cell transplant could be expected.

Source: Cancer Study UK 

‘This sounds apparent but you all of a sudden discover you inexplicably unhappy that the nurses are no lengthier asking you for Esme’s heart fee or temperature each few hours.

‘At a single position I even found myself crying when I bumped into another boy or girl being wheeled to theatre and realised Esme will never have an additional basic anaesthetic.

‘Instead, acquiring in advance of Esme’s agony has become a total-time occupation for us and the team, and Ezzie is now on an ever-escalating day-to-day combine of paracetamol, topical morphine, oxycodone, ketamine and, most recently, methadone.’ 

They also explained how Esme experienced been bedridden for 3 months and would never ever walk once more.

But the tot experienced her possess Xmas tree and was even taken out of the Royal Marsden Healthcare facility over the festive time period to see Christmas lights in Morden before a screening of Frozen 2 at Everyman Esher.

Now Will and Rebecca, of West Norwood, south London, hope to donate revenue in Esme’s name. They have by now lifted £425,000 on GoFundMe.

Rebecca mentioned in November: ‘When we commenced fundraising we have been punchy with our target to ensure we had more than enough for a self-funded transplant and reported that regardless of what remained would go to the CCLG, the UK’s main children most cancers charity.

‘Given how desperately bad the funding is into paediatric AML analysis, we sense even additional strongly about this now.

‘So a huge chunk of the money we have remaining (after expending some on novel medicines and supportive care) will be donated to AML investigation to attempt and spare potential family members the discomfort and anguish we have experienced.’



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